Septra IV Dosing
mg of Trimethaprim needed
ml's of Trimethaprim (Septra)
Dosing based on mg/kg per dose
interval in hours
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6
8
12
Total daily dose of trimethaprim in mgs
Dosing based on mg/kg per day
mgs of trimethaprim per day
Patient weight in kilograms
Patient weight in kilograms
mg/kg per day total
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12
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20
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interval in hours
mg per dose
select
6
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Adult Dosing
General:
160 mg PO BID
(all amounts based on TMP)
Severe Infections:
8-10 mg/kg/day div q6
-
12hr
IV
Pneumocystis carinii Pneumonia (PCP):
15-20 mg/kg/day div q6hr IV/PO
PCP
prophylaxis:
5-10 mg/kg/d
div q12hr IV/PO x3 consec. days/wk
Urinary Tract Infections (UTI),
Prophylaxis (
Off-label
): 40-80 mg PO daily
Renal Impairment
CrCl 15-30 mL/min: 1/2 dose
CrCl <15 mL/min: do not use
Pediatric Dosing
>2 mo, <40 kg: (all amounts based on TMP)
8 mg/kg/d
ay
div q12hr PO
Severe Infections:
as
adult
PCP
prophylaxis: as
adult
OR
150 mg /sq.meter/day div q12hr
on 3 consec days/wk IV/PO
Patient weight in kilograms
Dose in mg/kg as Trimethaprim
mls of trimethaprim (Septra per dose)
IV Info
IV Incompatibilities
Additive: fluconazole, linezolid, verapamil
Y-site: cisatracurium (incompatible at 2 mg/mL cisatra; may be compatible atmuch lower concs),
fluconazole, foscarnet (maybe compatible at very low TMP/SMX concs), midazolam, vinorelbine
IV Preparation
Do not use NS as diluent
Injection vehicle contains benzyl alcohol & sodium metabisulfite
Stability of parenteral admixture at room temperature (250C)
5 mL/125 mL D5W: 6 hr
5 mL/100 mL D5W: 4 hr
5 mL/75 mL D5W: 2 hr
IV Administration
Infuse over 60-90 min
Must be diluted well
May be given less diluted in a central line
Not for IM use
Maintain adequate fluid intake to prevent crystalluria
Administer around-the-clock every 6-12 hr
Storage
Do not refrigerate injection
Less soluble in more alkaline pH
Protect from light