Xigris dosing worksheet    Actual body weight in kilograms Dosing is 24 mcg/kg/hr for 96 hrs based on actual body weight Dose in mcg/kg/hr is Dose in mg/kg/hr is Dose in mls/hr using a 200 mcg/ml infusion solution is Preparation of infusion soultion Total mg's need for 96 hours of therapy is Number of 5 mg vials for 96 hours of therapy is Number of 20 mg vials needed for 96 hours of therapy   





















Reconstitute each vial of Xigris with Sterile Water for Injection, USP. The 5 mg vials must be     
reconstituted with 2.5 mL; the 20 mg vials with 10 mL. Slowly add the Sterile Water for Injection, USP to the vial and avoid inverting or shaking the vial. Gently swirl each vial until the powder is completely dissolved. The resulting Xigris concentration of the solution is 2 mg/mL.







To use all 5 mg vials of a solution containing 10 mg/ 50 ml use the following quidelines




            










Xigris should be administered via a dedicated intravenous line or a dedicated lumen of a multilumen venous catheter. The ONLY other solutions that can be administered through the same line are 0.9% Sodium Chloride Injection, USP; Lactated Ringers Injection, USP; Dextrose Injection, USP; and  Dextrose and Sodium Chloride Injection, USP.